Rams let a winnable Thursday slip away in OT against a short-handed 49ers, leaving Sean McVay furious and fantasy managers weighing risk and reward. Los Angeles sits at 3-2 after two gut-punch losses, with critical mistakes in special teams and ball security dragging down the win column. Puka Nacua remains the engine of the attack, piling up targets and yards behind a prolific Stafford, who’s averaging 300+ passing yards per game. Next up: a tough Baltimore test, then a London clash with Jacksonville.

Rams head to Philadelphia for a key road test with an injury-riddled depth chart. Ahkello Witherspoon is out with a broken clavicle; Steve Avila’s ankle and Braden Fiske’s status linger, Colby Parkinson was limited after missing Sunday; Havenstein and Davante Adams rested. Eagles list Will Shipley out, with Jalen Carter and Dallas Goedert limited. The updates tighten fantasy maps across pass-catchers and blockers, elevating depth players and testing the game plan.

Expect Rams to explore run-heavy drives and quick passes while backups step into bigger roles on both sides. Eagles fans and fantasy managers should watch late-week notes for shifts in target shares and line alignment, since these injury flags can swing Week 3 upside for non-elite options and spark sleeper plays in DFS.

Sean McVay’s foot issue kept him from appearing on the Rams’ injury report, but the coach will be on the sideline for a Sunday showdown with the Philadelphia Eagles, the reigning NFC champs who sit 2-0 after beating Dallas and Kansas City. LA added Tre Brown to shore up a depleted secondary after Ahkello Witherspoon landed on IR with a clavicle injury. Brown, a former Seahawk with 39 games and 13 starts, joins Cobie Durant, Emmanuel Forbes Jr and Darious Williams in a CB group that has extra pressure heading into a tough test.

The move mirrors the pursuit of depth as the Rams balance a banged-up unit with a high-profile opponent. The Eagles, built to attack, provide a clear measuring stick for the Rams’ revamped pass defense and the progress of young corners in Forbes Jr and Durant, supplemented by Williams and Brown as needed. Tennessee’s victory over the Rams last week is part of the backdrop for a game that could shape early-season narrative lines for fantasy managers.